Hendrie has performed voices on the animated FOX sitcoms King of the Hill and Futurama, and as I.N.T.E.L.L.I.G.E.N.C.E, Hanns Blix, and the Terrorist in Team America: World Police. In Spring of 2006, he had a supporting role in the live-action NBC sitcom Teachers.
Hendrie was married in 1997 to radio talk show host Maria Sanchez. Their wedding was held at the Queen Mary and was broadcast live on KFI. Hendrie moved from Minneapolis and then to Miami where he further developed his show. The show then moved to KFI in Los Angeles and was nationally syndicated to approximately 100 radio stations. In February 2005, Hendrie was moved from his flagship station, KFI, to XTRA Sports 570 AM, a sports talk radio station also centered in Los Angeles.
In early 2006, Hendrie announced that he would be ending The Phil Hendrie Show, feeling he had reached the limits of what he could do in "terrestrial talk radio" and expressing a desire to shift his career focus toward acting. His last radio broadcast was June 23, 2006. On December 4, 2006, in a radio interview, he mentioned that he may soon be returning to radio, but the show will not include his character skits. On June 4, 2007, it was announced that Phil Hendrie will return to radio June 25, 2007 from 10 PM to 1 AM PST on Talk Radio Network, with shows airing weeknightly. The new incarnation of Hendrie's program is a combination of character voices from his old show and lighthearted political commentary.
Hendrie considers his views unique for modern talk radio: on one hand, he is a registered Democrat who vocally supported Bill Clinton, voted for Al Gore over George W. Bush in 2000, both Jimmy Carter and Walter Mondale over Ronald Reagan in the 1980s, and Michael Dukakis over George H.W. Bush (although Hendrie claims "I had to hold my nose when voting for Dukakis"). Hendrie is also adamantly pro-choice, pro-gay marriage, and pro-amnesty for illegal immigrants. At the same time, he is extremely supportive of the Iraq War as well as the War on Terror. He voted for and suppor